*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

• Provide a Multifaceted Approach to Bone Maintenance and Strength*
• Provide Foundational Bone Support with Silica from Bamboo Extract)
  
• Support Bone Collagen Formation, Bone Mineral Density, and Bone Calcium Binding Sites*
  
• Provide a Complementary Combination of Micronutrients*

HydroxyBMD AM is our calcium/MCHC-free formula that combines Bonolive® olive extract with, D3, and MK-7 to provide bone and cardiovascular support.*

Bonolive Olive Leaf Extract
Bonolive is a pharmaceutical-grade olive leaf extract that features a unique polyphenol complex (40% polyphenols), including oleuropein. This proprietary olive extract preparation is fully water-soluble, which makes its oral bioavailability superior. Historical and traditional use, as well as clinical testing and toxicological assessment, confirm the safety of its oral consumption.[1,2]

Research has shown that olive polyphenol bioactivity is associated with increased osteoblast formation, increased extracellular matrix mineralization, and overall bone maintenance.[3] Five preclinical studies in a well-established rat model for bone health demonstrated that olive polyphenols exert protective effects on the formation and maintenance of bone.[4,5] In addition, a randomized, double-blind, placebo-controlled clinical study provided strong support for Boneolive promoted a statistically significant improvement (32% increase) in levels of the bone formation marker osteocalcin over a 12-month period. Furthermore, DEXA scan results suggested that Bonolive supplementation positively supported BMD at the lumbar spine and the femur neck compared to a placebo.[6] The treatment group also experienced reduced adipocyte formation and a positive effect on lipid metabolism (i.e., cholesterol and triglycerides), confirming Boneolive’s double mode of action: 
To positively influence bone health and cardiovascular health.

HydroxyBMD AM Supplement Facts (above)

Directions:
Take one packet daily in the morning.

(Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Consider total vitamin K intake (food + supplements) if you are taking blood-thinning medication. Do not use if tamper seal is damaged.)

Does not contain: Wheat, gluten, yeast, soy protein, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organism (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Storage: Keep tightly closed in a cool, dry place out of reach of children.

• Supports Bone Metabolism*
  
• Supports Bone Strength*
  
• Provides Micronutrients for Utilization in Bone Production and Structure*

Featuring

A WINNING PLAN: 

Your Doctor's Guidance

Your Micro-Nutrients

Your Micro-Impact

PLUS

The Benefits of

Bonolive^® is a trademark of BioActor.

- BonOlive provides powerful antioxidant support at the cellular level*
- BonOlive helps support cardiovascular health*
- BonOlive may improve bone health*

- Now has also been shown to reduce joint pain.
- Non-GMO, Soy Free, Gluten Free, Vegan

Olive fruits provide essential components of the Mediterranean diet known for being associated with improved cardiovascular and overall health.[1,2] Historically, olive leaves have been used in folk remedies to improve digestive, cardiovascular, and skin conditions. One of the key components in BONOLIVE is oleuropein, a powerful phytonutrient unique to the olive tree. At a cellular level oleuropein promotes bone formation by inhibiting adipocyte differentiation, and enhancing differentiation into osteoblasts.[3,4,5,6]

In the past years, interest in natural antioxidants as bioactive components of food has been rising. The positive effects of diets rich in fruits, vegetables and olive oil on overall health have been attributed partly to certain compound as phenolic compounds.[*3] Oleuropein gives the bitterness taste of olive oil but is also the major phenolic compound in olive leaves that has been studied for its antioxidant activity involving in promising results with respect to its effect on human health.[*3,5,7] The daily consumption of olive oil in population that follow the Mediterranean diet, provides enough oleuropein in the body to supply protection against free radicals and lipid peroxidation in humans.[*8] The antioxidant abilities, the scavenging abilities, the chemistry and pharmacological aspects of oleuropein have been widely studied and are well known.[7,9,10]

provides powerful antioxidant support at cellular level

For decades, the Mediterranean diet has been considered to be one of the most healthy. In the 1960's, scientific works started to observe the positive effect of overall cardiovascular health in population that followed the Mediterranean diet.[*11] Olive oil is the most popular dietary liquid from the Mediterranean diet and much of the evidence of its beneficial health is attributed to oleuropein, the major phenolic in olive leaves.[12,13,14,15,16]

Epidemiological studies have shown that the incidence of bone loss was lower in the Mediterranean basin where traditional Mediterranean diet that include consumption of olive oil is widely consumed by the population.[17] Moreover, experimental models have been able to show that oleuropein is the phenolic compound from olive leaves involved in hindering, the loss of bone mass suggesting its possible key role in improving bone health.[*18,19]

helps support cardiovascular health*

may improve bone health*

^®

^®

^®

^®

Naturally Supporting Healthy & Balanced Bone Metabolism

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Clinically Proven

BonOlive is a clinically proven bone health supplement. A randomized, double-blind, placebo-controlled study proved that BonOlive has significant effects on stimulation of bone building cells (osteoblasts) and blood liquid profiles.

The figure illustrates the 32% increase in osteocalcin levels over 12 months, which was statistically significant and indicates an increase in osteoblast activity (bone formation). Also blood liquid markers improved. A significant treatment effect was observed for total cholesterol LDL-cholesterol and triglyceride levels. Finally, DEXA scans showed subjects taking BonOlive displayed a protection of bone mineral density at the femur neck compared to those taking placebo.

Superior Bioavailability

Furthermore, results of a pharmacokinetic study shown the intake of BonOlive leads to an excellent bioavailability of bioactive metabolites in the target population for use of BonOlive.

Dr. M.Taher Fouad founded Biotron Laboratories in 1979. His passion for health and science converged in his commitment to discovering the role of minerals and trace elements in the human body. Biotron's history is inextricably linked to Mineral Amino Acid Chelates and their role in human nutrition, and Dr. Fouad's pioneering of these efforts. Today Biotron carries forward Dr. Fouads's lifework with a primary focus on scientifically validated mineral chelates and complexes.

Following in his father's footsteps, Dr. Gameil T. Fouad now presides over daily operations at Biotron. Gameil earned his B.S. in Human Biology at the University of Utah and went on to earn his Ph.D. at the Department of Molecular and Medical Genetics at the Oregon Health & Science University.

In his role as President, Gameil approaches mineral nutrition from a unique industry perspective, bringing new ideas to bear on minerals. Along with his expert team, Gameil actively applies these tools to the health and nutrition field with the aim of developing mineral products that are highly compatible with human physiology on a molecular level.

To date, the Biotron Process has achieved widespread recognition as a unique and scientifically valid technique, which utilizes the complete amino acid profile derived from enzymatic treatment of isolated vegetable proteins–a process resulting in authentic Mineral Amino Acid Chelates and Complexes.

Chelated Minerals for Human Nutrition - Calcium is essential

What makes this Professional Quality 

Bone Health System so Unique?

                 a pharmaceutical-grade olive leaf extract which improved bone and cardiovascular health in clinical studies^[1-19].

HydroxyBMD AM: A Calcium Free (CF) option. 

HydroxyBMD PM: A chelated, natural calcium/mineral add-on allowing you and your physician to decide how much calcium and minerals are right for you.

A New Zealand microcrystalline hydroxyapatite concentrate
(MCHC): a complex crystalline compound containing numerous
essential trace elements that naturally occur in healthy bone.

Patented Chelated Calcium 
for maximum bioavailability.

A whole food form of silica that assures maximum absorption.

^®

HydroxyBMD PM is a well-researched, standardized extract from one of the world’s safest premium sources of bone - free-range New Zealand cattle. 
HydroxyBMD PM contains microcrystalline hydroxyapatite concentrate (MCHC), a complex crystalline compound containing calcium, phosphorus, bioactive growth factors, type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements that naturally comprise healthy bone.*

HydroxyBMD PM delivers 250mg of MCHC per capsule along with additional calcium and magnesium in the form of highly absorbable Cytocal, Vitamin D, in the form of cholecalciferol, supports intestinal calcium absorption and homeostasis in the body and completes the comprehensiveness of this bone-support formula.*

HydroxyBMD PM Supplement Facts (above)

Directions:
Take two capsules with your meal daily in the afternoon/evening.

(Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged. The labeling on this product does not comply with California’s Proposition 65. Therefore, this product may not be sold in California.)

Does not contain: Wheat, gluten, yeast, soy protein, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organism (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Storage: Keep tightly closed in a cool, dry place out of reach of children.

SOLVING THE  BONE HEALTH PUZZLE 

GET SERIOUS ABOUT YOUR BONE HEALTH 

JUVENT Micro-Impact Platform

Scientific References BONOLIVE
1. Covas M, Ruiz-Gutierrez V., De La Torre R, et al. Minor Components of Olive Oil: Evidence to Date of Health Benefits in Humans.  Nutr Rev. 2006;64:20-30.
2. Buckland G. and Gonzales CA. The role of olive oil in disease prevention: a focus on the recent epidemiological evidence from cohort studies and dietary intervention trials. Brit J Nutr. 2015;113:S94-S101.
3. Benavente-Garcia O, Castillo J. Lorente J et al. Antioxidant activity of phenolics extracted from Olea europaea L. leaves. Food Chem. 2000;68:457-462.
4. Ghedira K. L’olivier. Phytotherapie. 2008;6:83-89.
5. Barbaro B, Toietta G, Maggio R et al. Effects of the olive-derived polyphenol oleuropein on human health. Int J Mol Sci. 2014;15:18508-15524.
6. Ben Salem M, Affes H, Ksouda K, et al. Pharmacological Activities of Olea europaea Leaves. J Food Processing and Preservation. 2015;39:3128-3136.
7. Wichers HJ, Espin JC and Soler-Rivas C. Oleuropein and related compounds. J Sci Food and Agric. 2000;80:1013-1023.
8. Perona JS, Cabello-Moruno R and Ruiz-Gutierrez V. The role of virgin olive oil components in the modulation of endothelial function. J Nutr Biochem. 2006;17:429-445.
9. Tuck KL and Hayball PJ. Major phenolic compounds in olive oil: metabolism and health effects. J Nutr Biochem. 2002;13:636-644.
10.Tripoli E, Giammanco M, Tabacchi G et al. The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health. Nutr Res Rev. 2005;18:98-112.
11.Psaltopoulou T, Naska A, Orfanos P, and al. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. The American journal of clinical nutrition. 2004;80:1012.
12.Covas MI. Olive oil and the cardiovascular system. Pharmacol Res. 2007;55:175-186.
13.Zacharias E. The Mediterranean Diet: A Clinician’s Guide for Patient Care. Publisher: Springer New York. 2012.
14.Waterman E. and Lockwood B. Active components and clinical applications of olive oil. Alternative medicine review: J Clin Ther. 2007;12:331.
15.Omar SH. Oleuropein in olive and its pharmacological effects. Scientia pharmaceutica. 2010;78:133-154.
16.Preedy VR, Watson RR. Olives and Olive Oil in Health and Disease Prevention. 1st ed. Amsterdam; Boston: Elsevier/Academic Press; 2010;2013.
17.Santiago-Mora R, Casado-Diaz A. De Castro MD et al. Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow. Osteoporosis Int. 2011;22:675-684.
18.Puel C, Mathey J, Agalias A et al. Dose-response study of effect of oleuropein, an olive oil polyphenol in an ovariextomy/inflammation experimental model of bone loss in the rat. Clin Nutr. 2006;25:859-868.
19.Garcis-Martinez O, Rivas A, Ramos-Torrecillas J. et l. The effect of olive oil on osteoporosis prevention. Int J Food Sci nutr. 2014;65:834-840.

Scientific References for HydroxyBMD AM's Formulation
1. Filip R, Possemiers S, Heyerick A, et al. Twelve-month consumption of a polyphenol extract from olive in a double blind, randomized trial increases serum total osteocalcin levels and improves serum lipid profiles in postmenopausal women with             osteopenia. J Nutr Health Aging. 2015 Jan; 19(1):77-86. [PMID:9483660] 
2. Clewell AE, Beres E, Vertesi A., et al. A comprehensive toxicological safety assessment of an extract of Olea Europea L. leaves (Bonolive^TM). Int J Toxicol. 2015 Dec 10. pii: 1091581815619764. Epub ahead of print.[PMID: 26658007 
3. Santiago-Mora R, Casado-Diaz A, De Castro MD, et al. Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone narrow. Osteoporos Int. 2011 Feb;22(2):675-84. [PMID: 20495905] 4. Puel C, Mardon J, Agalias A, et al. Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model. J Agric Food Chem. 2008 Oct. 22;56(20):9417-22. [PMID: 18800805] 
5. Puel C, Mahey J, Agalias A, et al. Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat. Clin Nutr. 2006 Oct;25(5):859-68.[PMID: 16740345]. 
6. Puel C, Quintin A, Angalias A, et al. Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat. Br J Nutr. 2004 Jul;92(1):119-27. [PMID: 15230995] 
7. Puel C, Mardon J, Kati-Coulibaly S, et al. Black Luques olives prevented bone loss caused by ovariectomy and talc granulomatosis in rats. Br J Nutr. 2007 May;97(50:1012-20. [PMID: 17408530] 
8. Hagiwara K, Goto T, Araki M, et al. Olive polyphenol hydroxytyrosol prevents bone loss. Eur J Pharmasol. 2011 Jul 15;662(1-3):78-84. [PMID: 21539839]

Discover the many benefits of Our Unique Ingredients

All these Amazing Ingredients come together in the HydroxyBMD² System

In the Morning:

In the Evening:

Interview with Sam Possemiers, PhD Research Director, BioActor (Graduated from Ghent University)

Where nutritionally essential minerals are concerned, calcium is truly in a class by itself. The daily requirements for calcium are over 1,000 milligrams per day for most adults. It is hard to overemphasize the roles calcium plays in the body. Calcium is involved in a wide array of biological processes - from intracellular signaling to neurotransmission and muscle contraction. Despite these various functions, it is calcium's definitive role in supporting bone health that makes this nutrient so vital. It's one of the few essential nutrients for which an FDA-approved claim can be made. It is difficult to overemphasize the importance of achieving peak bone mass in adolescence and early adulthood to minimize the risks of osteoporosis later in life. 

Unfortunately, most women fail to get enough calcium from diet alone. For many, supplementation is indispensable to achieving adequate daily intake. Not all forms of calcium are created equally and controversy over which type is best continues to be a matter of debate. Its thought that organically-bound calcium is preferentially absorbed when compared to widely used inorganic forms such as calcium carbonate. Demonstrating this experimentally is challenging. Because if its importance, calcium levels in the blood are very tightly regulated by the body. Parathyroid hormone (PTH) - among other hormonal control systems - function to maintain this delicate balance. 

NEW & IMPROVED

Glass bottles - no more plastic pollution and bisphenols

Easy to swallow capsules - no tablets

Lower Price - 30-40% less cost

The best ingredients

No Strontium

A Whole Food Silica

We took all of your feedback and the latest research and built a better supplement.